Rosetta Software
- While much traditional protein modeling software takes a pure first-principles approach using deep expert knowledge of physics and chemistry, and modern AI tools often take a model-free approach based entirely on data, the Rosetta software package takes a combined approach based on physics and on statistical patterns. This combination, along with a relentless focus on the prediction of experimental characteristics and benchmarking to wet lab data, has made Rosetta uniquely useful for protein design in the lab
- Rosetta has been responsible for all of the major “firsts” in computational protein design, including protein binder design, de novo protein design, and macromolecular assembly design.
- There are thousands of published papers on protein design using Rosetta that demonstrate a wide range of capabilities in the laboratory.
- Rosetta software is making an active impact on drug discovery: As of 2021, multiple clinical stage protein biologics, a half dozen IND stage molecules and over a dozen pre-clinical stage biologics have been developed
Rosetta Software
- While much traditional protein modeling software takes a pure first-principles approach using deep expert knowledge of physics and chemistry, and modern AI tools often take a model-free approach based entirely on data, the Rosetta software package takes a combined approach based on physics and on statistical patterns. This combination, along with a relentless focus on the prediction of experimental characteristics and benchmarking to wet lab data, has made Rosetta uniquely useful for protein design in the lab.
- Rosetta has been responsible for all of the major “firsts” in computational protein design, including protein binder design, de novo protein design, and macromolecular assembly design.
- There are thousands of published papers on protein design using Rosetta that demonstrate a wide range of capabilities in the laboratory.
- Rosetta software is making an active impact on drug discovery: As of 2021, multiple clinical stage protein biologics, a half dozen IND stage molecules and over a dozen pre-clinical stage biologics have been developed.
ROSETTA & CYRUS SOFTWARE
Cyrus Software Platform
- The largest and most experienced industrial Rosetta team
- Proprietary Rosetta protocols (for example, our antibody structure prediction pipeline,[LINK to antibody press release])
- Proprietary combined Rosetta/AI algorithms (deimmunization, solubility enhancement)
- Proprietary cloud workflow automation
- In-house protein structure and data analysis (automated small molecule handling, non-canonical amino acids parameterization)
- Protocols trained, tested, and validated on in house and partner proprietary data sets
Cyrus Software Platform
- The largest and most experienced industrial Rosetta team
- Proprietary Rosetta protocols (for example, our antibody structure prediction pipeline,[LINK to antibody press release])
- Proprietary combined Rosetta/AI algorithms (deimmunization, solubility enhancement)
- Proprietary cloud workflow automation
- In-house protein structure and data analysis (automated small molecule handling, non-canonical amino acids parameterization)
- Protocols trained, tested, and validated on in house and partner proprietary data sets
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