Cyrus: Rosetta Computational Protein Modeling and Design Software

  • Rosetta software is responsible for the key firsts in computational protein design including the first de novo designed protein (Top7), designed enzymes, and high-affinity protein binders via protein interaction design.
  • Multiple Rosetta engineered proteins are in pre-clinical or clinical testing at numerous companies including Tocagen, PvP Biologics, Arzeda, Neoleukin, Sana, Lyell and a variety of other BioPharma companies. No other computational protein engineering platform can make a similar claim.
  • Computational protein design improves on rational protein engineering and acts as a complement to protein selection and screening methods such as yeast surface display, especially in combinatoric cases requiring many mutations to improve activity, in de novo protein design (not related to natural proteins), in cases where extensive experimental testing is difficult/expensive, or in order to create a more diverse set of high-activity mutants or identify novel mutants that are not identified in library screens.
  • Key Rosetta software use cases: Protein structure prediction (homology modeling), Protein engineering for stability, protein design for solubility or immunogenicity especially for biologics, protein interaction engineering for higher affinity or specificity, enzyme engineering for higher activity or specificity, and design of protein mutational libraries for selection experiments.
  • Rosetta software from David Baker’s lab at the Institute of Protein Design and over 50 other institutions has been extensively validated in more than a thousand publications, including more than 60 publications in high profile journals like Nature, Science and Cell. Rosetta has continued to be a leader in protein structure prediction and protein modeling at the CASP and CAMEO evaluations.
  • Rosetta is now available in an easy-to-use form as Cyrus Bench, including training videos and optional professional scientific support.