Rosetta has pioneered major advances in the field of structure determination from CryoEM data. Major achievements in the CryoEM field using Rosetta include:
Solving models otherwise impossible using other approaches
Refining structures to far better effective resolution than other approaches
Many high profile publications in journals such as Nature, Cell, and PNAS
Rosetta combines the world’s best protein structure refinement force field and approach with a demonstrably superior method for fitting a protein structure into a CryoEM derived map. The result is far better effective resolution than is possible with any other CryoEM refinement approach.
We offer collaborative flexibility in model building, structure refinement, or complete turnkey services from prepared sample to fully refined structures.
CryoEM data collection through partners
Structure refinement into density
Model building into density de novo
Model building with modifications, such as carbohydrates