Cyrus Biotechnology and OpenEye Scientific Software Announce Collaboration and Cheminformatics Integration to Expedite New Drug Design and Development with Cyrus Bench Platform

SEATTLE, WA October 30, 2018 — Cyrus Biotechnology, Inc., a Seattle-based biotech software company commercializing Rosetta, an advanced protein design platform, announced today that through a collaboration with OpenEye Scientific Software, Inc., a leader in computational molecular design, capabilities have been developed that allow small molecule ligands to be processed and used with Rosetta and within the Cyrus Bench® platform for computational protein drug design.  

“We are very excited to integrate these new ligand tools in our protein design platform,” said Cyrus CEO Dr. Lucas Nivon. “Previously scientists have had to endure incompatible tools and sub-par results when carrying out protein-ligand modeling, but with the new automated small molecule integration, we have created a straightforward and reliable tool our customers can use to design new therapeutics and industrially useful enzymes.”

Rosetta software is the world leader in protein modeling and design. However, including small molecule ligands when using Rosetta has been problematic, severely limiting its utility for many pharmaceutical, consumer products and other applications where protein/small-molecule interactions are critical.

Cyrus has developed new scientific tools that integrate OpenEye’s cheminformatics and modeling technologies to allow Cyrus customers to:

  • Parameterize small molecules robustly and with high accuracy
  • Carry out enzyme and general protein design in the presence of a ligand.  

OpenEye CEO, Dr. Anthony Nicholls, said, “We are excited to be a part of Cyrus Bench® by providing OMEGA, the world’s best validated and industry-leading conformer generation tool, along with OpenEye’s robust and highly performant cheminformatics and modeling

capabilities. We look forward to seeing the science both companies will enable by this partnership.”

OpenEye has been a leader in cheminformatics and molecular modeling for over twenty years. OpenEye’s toolkit platform allows flexible and powerful workflow integration with Cyrus Bench and Rosetta software. Robust and seamless support for state-of-the-art small molecule/protein interactions is now available to Bench users.

This software integration has been tested and debugged on thousands of examples from the Protein Data Bank and will robustly allow small molecules to be included in most Rosetta calculations in Bench.

This new set of tools for protein modeling in the presence of arbitrary small molecules—utilizing a simple-to-use Rosetta GUI–is now available to existing subscribers to Cyrus Bench® and can be accessed by new customers by subscribing to the Cyrus Bench® suite of tools.

Cyrus Biotechnology

Cyrus Biotechnology, Inc. is a privately-held biotechnology software company offering protein modeling and design capabilities to the Biotechnology, Pharmaceutical, Chemical, Consumer Products and Synthetic Biology industries. Cyrus was founded in 2014 as a spin-out from the University of Washington, and offers Cyrus Bench®, a Software-as-a-Service (SaaS) platform for protein structure prediction via homology modeling, protein modeling, protein stabilization, protein engineering and protein design to accelerate discovery of biologics and small molecules. Cyrus Bench is based primarily on the Rosetta molecular modeling and molecular design software package from the laboratory of Prof. David Baker at the University of Washington, along with associated software. Cyrus Bench offers the world-leading protein structure prediction pipeline of Rosetta and SparksX, the top structure prediction software in the bi-annual CASP competition and the weekly CAMEO competition, as well as the only protein engineering software experimentally proven to design new proteins completely via software. Cyrus customers include 10 of the top 20 Global Pharmaceutical firms as well as smaller Biotechnology and Chemicals firms. Cyrus is financed by leading investors in both Technology and Biotechnology, including Trinity Ventures, Orbimed, Springrock Ventures, Alexandria Venture Investments, the W Fund, and others. For more information please visit

https://cyrusbio.com/  

OpenEye Scientific

OpenEye is a scientific leader in computational molecular design based on decades of delivering useful applications and programming toolkits. Our scientific approach changed perception of what’s possible with the speed, robustness and scalability of our tools. OpenEye recently released Orion, the only cloud-native fully integrated drug discovery platform, combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in an open development platform.  Founded in 1997, OpenEye Scientific Software Inc. is a privately held company headquartered in Santa Fe, NM, with offices in Boston, Cologne and Tokyo. For more information please visit https://www.eyesopen.com

NOTICE: The information contained in this document is dated as of October 30, 2018.  Cyrus Biotechnology, Inc. (the Company) disclaims any obligation to update such information after such date.  This document contains forward–looking statements reflecting the Company’s current expectations that necessarily involve risks and uncertainties.  Actual results and the timing of events may differ materially from those contained in such forward-looking statements due to a number of factors and the Company undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Cyrus Press Release 10/30/2018

Cyrus Contact – Lucas Nivon
lucas@cyrusbio.com
206-258-6561

OpenEye Contact – Fred Livingston
info@eyesopen.com

Cyrus Biotechnology to Present at the Immunogenicity & Bioassay Summit on October 25, 2018

SEATTLE, WA October 12, 2018 — Cyrus Biotechnology, a Seattle-based firm offering access to Rosetta, the most advanced software available for protein modeling and accelerated drug discovery, announced today that it will present at the 10th Annual Immunogenicity & Bioassay Summit, to be held in Washington DC on October 22-25, 2018.

Dr. Indigo King, a computational protein design and immunology specialist, will present at the Immunogenicity Summit as follows:

Abstract: Computational protein design has the potential to create a novel class of therapeutics with tunable biophysical properties, but immunogenicity remains a concern. We have combined machine learning with structure-based protein design to identify and redesign T-cell epitopes without disrupting function of the target protein or creating new epitopes. We have verified the method experimentally, removing T-cell epitopes from a gene therapy target, an immunotoxin, and GFP while maintaining folding and function.

Date: Thursday, October 25th, 2018

Time: 3:25 PM EDT

Track: Immunogenicity Prediction & Control

Room: Edison ABC

Venue: The Westin Alexandria, 400 Courthouse Square, Alexandria, VA 22314

For more information on immunology with Cyrus, see Cyrus Biotechnology Launches Immune Epitope Prediction Software.

 

Cyrus Biotechnology

Cyrus Biotechnology, Inc. is a privately-held biotechnology software company offering protein modeling and design capabilities to the Biopharmaceutical, Chemical, Consumer Products and Synthetic Biology industries. Cyrus was founded in 2014 as a spin-out from the University of Washington, and offers Cyrus Bench®, a Software-as-a-Service (SaaS) platform for protein structure prediction, modeling, stabilization, engineering and design to accelerate discovery of Biologics and Small Molecules. Cyrus Bench is based primarily on the Rosetta software package from Prof. David Baker’s lab at the University of Washington, along with associated software. Cyrus Bench offers the world-leading protein structure prediction pipeline of Rosetta, as well as the only protein engineering software experimentally proven capable of designing entirely new proteins. Cyrus Bench is powered by Rosetta, which has been developed over near 20 years, and validated by well over 700 publications that demonstrate efficacy both in vitro and in vivo. Cyrus is financed by experienced investors in both Technology and Biotechnology, including Trinity Ventures, Orbimed, Springrock Ventures, Alexandria Real Estate, the W Fund, and others.

NOTICE: The information contained in this document is dated as of October 12, 2018.  Cyrus Biotechnology, Inc. (the Company) disclaims any obligation to update such information after such date.  This document contains forward–looking statements reflecting the Company’s current expectations that necessarily involve risks and uncertainties.  Actual results and the timing of events may differ materially from those contained in such forward-looking statements due to a number of factors and the Company undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Cyrus Press Release 10/12/2018

 

Cyrus Contact Lucas Nivon
lucas@cyrusbio.com
206-258-6561

Cyrus Biotechnology Appoints Jake Litwicki as VP of Engineering

Cyrus growing its team to speed biologics and small molecule
drug development software to market

SEATTLE, WA August 6, 2018 — Cyrus Biotechnology, a biotechnology software company
offering first-in-class tools for advanced protein modeling and discovery in drug development,
announced today the appointment of Jake Litwicki as VP of Engineering. Jake will lead software
engineering for the Cyrus Bench Software as a Service platform which speeds development of
new drugs and products sold to client firms in pharmaceuticals, biotechnology therapeutics,
synthetic biology and consumer products. Jake’s team will continue to grow the Cyrus Bench
toolkit, and add valuable new features including tools for antibody and biologics discovery as
well as small molecule modeling and discovery.  Prior to joining Cyrus Jake led software
engineering teams and spearheaded the transition to more modern cloud architectures at a
custom software development firm, a marketing technology startup, and most recently as the
leader of the Platform, Global and Microservice teams at Sterling Talent Solutions.
“Jake is a seasoned technical leader with experience across a variety of company and team
sizes, with a proven ability to bring widely used software to the market and to drive
improvement and best practices in an engineering organization,” said Dr. Lucas Nivon, CEO of
Cyrus. “Jake’s passion for software engineering, architecture and leadership will make him an
important part of our growth as we add scientific users at companies worldwide.”
“Cyrus is a unique organization with the potential to literally change the world for the better.
Having the opportunity to contribute to something with that kind of impact is truly inspiring”,
said Jake.  “I am eager to help grow and evolve the Cyrus team into a world leader in both
biotechnology and software as a service”, he added.

Jake’s team at Cyrus will be responsible for software frontend, backend, testing and release of
new scientific features developed by the open source RosettaCommons community, by other
Cyrus partners, or by Cyrus’s scientific software development and infrastructure team. Cyrus
software and services are currently being utilized by multiple companies including 10 of the top
20 Global Pharmaceutical firms, not only to design new drugs but also to offer solutions for
problems in drugs already under development.

Cyrus Biotechnology, Inc. is a privately-held biotechnology software company offering protein
modeling and design capabilities to the Biotechnology, Pharmaceutical, Chemical, Consumer
Products and Synthetic Biology industries. Cyrus was founded in 2014 as a spin-out from the
University of Washington, and offers Cyrus Bench®, a Software-as-a-Service (SaaS) platform for
protein structure prediction, modeling, stabilization, engineering and design to accelerate
discovery of Biologics and Small Molecules. Cyrus Bench is based primarily on the Rosetta
software package from Prof. David Baker’s lab at the University of Washington, along with
associated software. Cyrus Bench offers the world-leading protein structure prediction pipeline
of Rosetta and SparksX, the top structure prediction software in the bi-annual CASP
competition and the weekly CAMEO competition, as well as the only protein engineering
software experimentally proven to design new proteins completely via software.. Cyrus in
financed by leading investors in both Technology and Biotechnology, including Trinity Ventures,
Orbimed, Springrock Ventures, Alexandria Venture Investments, the W Fund, and others.

Cyrus is featured in: Built In Seattle’s 50 Startups to Watch in 2018

Cyrus Biotechnology offers molecular scientists a cloud-based platform that allows them to design and build protein molecules. The software is based on a protein-modelling platform called Rosetta, which was first conceived and created at the University of Washington, and essentially allows the creation of entirely new types of proteins inside a computer. Cyrus Biotechnology brings this capability to the market with a software package which includes, among other things, a visual representation of proteins as a user constructs them.

Click here for full article.

Cyrus Biotechnology Launches Immune Epitope Prediction Software

SEATTLE  Cyrus Biotechnology, Inc., a Seattle-based firm offering access to Rosetta, the most advanced software available for protein modeling and accelerated drug discovery, announced today the general release of a new immune screening and prediction tool in their Cyrus Bench® platform.

Cyrus customers can now drastically reduce immunogenicity in pre-clinical candidates, thereby decreasing the chance of dangerous and costly adverse events during clinical trials.

Published work has demonstrated the effectiveness of combining this epitope prediction method with the powerful protein design algorithms in Rosetta. Two published examples show positive proof of drastic immunogenicity reduction, both in mice and ex vivo in human test subjects. Cyrus has carried out a third such study with an academic collaborator, which has been experimentally proven in animal models. The details of this study will be published separately.

The epitope prediction software is based on the carefully curated set of known MHC-II epitopes in the IEDB database. Those data were used to train a modern Machine Learning algorithm to detect likely new epitopes in proteins of interest. The algorithm was then refined with experimental data to confirm its scientific validity.

The immune epitope prediction and protein design algorithms are currently available to existing subscribers to Cyrus Bench® and can be accessed by new customers by subscribing to the Cyrus Bench® suite of tools.

Cyrus will introduce a novel, fully automated immune epitope removal software tool in the next few months as another valuable addition to the rapidly expanding capabilities in Cyrus Bench®. It will be the first commercially available software-based method proven to reduce immune liabilities in candidate biologics or already marketed biologics.

Cyrus Biotechnology

Cyrus Biotechnology, Inc. is a privately-held biotechnology software company offering protein modeling and design capabilities to the Biopharmaceutical, Chemical, Consumer Products and Synthetic Biology industries. Cyrus was founded in 2014 as a spin-out from the University of Washington, and offers Cyrus Bench®, a Software-as-a-Service (SaaS) platform for protein structure prediction, modeling, stabilization, engineering and design to accelerate discovery of Biologics and Small Molecules. Cyrus Bench is based primarily on the Rosetta software package from Prof. David Baker’s lab at the University of Washington, along with associated software. Cyrus Bench offers the world-leading protein structure prediction pipeline of Rosetta and SparksX, the top structure prediction software in the bi-annual CASP competition and the weekly CAMEO competition, as well as the only protein engineering software experimentally proven to design new proteins completely via software. Cyrus Bench is based on over 15 years of biochemistry software development and over 700 published papers demonstrating experimental efficacy in vitro and in vivo. Cyrus in financed by experienced investors in both Technology and Biotechnology, including Trinity Ventures, Orbimed, Springrock Ventures, Alexandria Real Estate, the W Fund, and others.

NOTICE: The information contained in this document is dated as of July 10, 2018. Cyrus Biotechnology, Inc. (the Company) disclaims any obligation to update such information after such date. This document contains forward–looking statements reflecting the Company’s current expectations that necessarily involve risks and uncertainties.Actual results and the timing of events may differ materially from those contained in such forward-looking statements due to a number of factors and the Company undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

Business Wire Release July 10, 2018

Contacts

Cyrus Biotechnology, Inc.
Lucas Nivon, 206-258-6561
lucas@cyrusbio.com

Cyrus Biotechnology Exhibits at the PEGS Protein Engineering Summit in Boston, April 30th – May 3rd

SEATTLE, April 18, 2018 — Cyrus Biotechnology, Inc., a biotechnology software company offering the most advanced protein modeling and design capabilities to the Biopharmaceutical, Synthetic Biology, Chemical, and Consumer Products industries is pleased to announce its participation in the 14th Annual PEGS Boston Protein Engineering Summit in Boston, from April 30th through May 3rd.

Dr. David Pearlman, Senior Fellow and Director of Customer Experience at Cyrus Bio, and Rosario Caltabiano, Executive VP of Sales, will attend the conference and discuss the latest advances in in silico protein engineering at booth 539 in the Boston Seaport World Trade Center Exhibit Hall. 

The Rosetta software package, from the RosettaCommons, is the premier software platform for advanced computational protein engineering. Cyrus has implemented the Rosetta stack with an easy to use interface on a public computing cloud, resulting in high reliability software with high performance and usability in a secure multi-tenant model. R&D organizations can remove large capital expenditures, avoid over- or under-provisioning, and maximize scientific output.

In silico modeling and design of proteins is becoming increasingly relevant to the pharmaceutical industry, as investment in research, development and clinical trials of biologic therapeutics continues to grow. Cyrus Bench® software, and the underlying Rosetta software package, are already leveraged by many global pharmaceutical organizations and are at the nexus of this major trend. Cyrus customers can apply the most advanced and validated in silico protein engineering science through an intuitive user interface for:

  • Protein Structure Prediction (best overall performance at CASP and CAMEO)
  • Protein Stabilization
  • Computational Affinity Maturation (Interface Design)
  • Prediction of Immunogenic Epitopes
  • Removal of Identified Liabilities
  • Protein Structure Optimization and Design
  • Antibody Engineering
  • Antigen Design

 

Background

Cyrus Biotechnology

Cyrus Biotechnology, Inc. is a privately-held biotechnology software company offering protein modeling and design capabilities to the Biopharmaceutical, Chemical, Consumer Products and Synthetic Biology industries. Cyrus was founded in 2014 as a spin-out from the University of Washington, and offers Cyrus Bench®, a Software-as-a-Service (SaaS) platform for protein structure prediction, modeling, stabilization, engineering and design to accelerate discovery of Biologics and Small Molecules. Cyrus Bench is based primarily on the Rosetta software package from Prof. David Baker’s lab at the University of Washington, along with associated software. Cyrus Bench offers the world-leading protein structure prediction pipeline of Rosetta and SparksX, the top structure prediction software in the bi-annual CASP competition and the weekly CAMEO competition, as well as the only protein engineering software experimentally proven to design new proteins completely via software. Cyrus Bench is based on over 15 years of biochemistry software development and over 400 published papers demonstrating experimental efficacy in vitro and in vivo. Cyrus is funded by experienced investors in Tech and Biotech including Trinity Ventures, Orbimed Advisors, SpringRock Ventures, W Fund and others.

NOTICE: The information contained in this document is dated as of April 18, 2018.  Cyrus Biotechnology, Inc. (the Company) disclaims any obligation to update such information after such date.  This document contains forward–looking statements reflecting the Company’s current expectations that necessarily involve risks and uncertainties.  Actual results and the timing of events may differ materially from those contained in such forward-looking statements due to a number of factors and the Company undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

 

Cyrus Press Release 04/18/2018

 

Contact Lucas Nivon
lucas@cyrusbio.com
206-258-6561

Cyrus Bio Co-Founder David Baker Featured in the New York Times

SEATTLE, WA January 02, 2018 — Prof. David Baker, Cyrus Bio Scientific Co-Founder and Director of the Institute for Protein Design at the University of Washington, and the Rosetta software, have been prominently featured in the December 26th, 2017 New York Times article by Carl Zimmer, “Scientists are Designing Artisanal Proteins for Your Body.”

The article illustrates how computationally building proteins from first principles are effectively targeting influenza, botulism, opioids, gluten intolerance, gene therapy and immuno-oncology.

Gary Nabel, Chief Scientific Officer at Sanofi, is quoted saying that “the new research may lead to the invention of molecules we can’t yet imagine.”

Cyrus Bench® is a Software-as-a-Service platform based on the Rosetta protein modeling toolkit for protein structure prediction, discovery, modeling, stabilization, engineering and design, making some of the methods developed at Prof. Baker’s lab available to a wider audience of scientific users in Pharmaceutics, Chemicals, Consumer Products, Academia and Non-Profits.

Click here to access the article. A subscription to the New York Times may be required.

 

Cyrus Biotechnology to Present at the Biotech Showcase™ Annual Conference on January 9, 2018

Cyrus Bio technology can speed new drug discovery

 

SEATTLE, WA December 29, 2017 — Cyrus Biotechnology, a biotechnology software company offering first-in-class tools for advanced protein modeling and discovery in drug development, announced today that it will present at Biotech Showcase™ 2018, to be held January 8–10 during the most important week in healthcare at the Hilton San Francisco Union Square.

 

Dr. Lucas Nivon, CEO, will present at the Biotech Showcase™ as follows:

Date: Tuesday, January 9th, 2018

Time: 2:00PM PST

Room: Franciscan D (Ballroom Level)

Venue:  Hilton San Francisco Union Square Hotel, 333 O’Farrell Street, San Francisco, CA

 

Cyrus offers Bench®, a Software-as-a-Service platform for protein structure prediction, biologics discovery, alternative structure modeling, protein stabilization, engineering and design, along with custom software development and experienced scientific support services in computational protein engineering.

 

Bench® is based on two decades of work in computational biophysics and the first software algorithms to design new proteins in a computer. It has been designed for a wider range of users than previous academic-based software. Cyrus is rapidly acquiring customers ranging from Fortune 500 Pharma (including eight of the top 20 Pharma firms), chemical and consumer products firms to privately-held biotech and synthetic biology firms.

 

Bench® is a graphical, cloud-enabled version of the Rosetta protein modeling toolkit. Data generated from Rosetta technology can be used in the design of new potential therapeutics, such as a therapeutic protein of Tocagen’s Toca 511 and PVP Biologics’ KumaMax, an oral enzyme. Cyrus is funded by leading investors in both Tech and Biotech sectors, led by Trinity Ventures with Orbimed, SpringRock, W Fund and others.

 

“We are very excited to be presenting at Biotech Showcase™,” said Cyrus CEO Dr. Lucas Nivon. “Year after year, our participation in the J.P. Morgan Annual Healthcare Conference has been fruitful and productive for the organizations we have established partnerships with. Our Bench® technology broadens access to the most advanced biocomputational methods, giving more scientists the means to speed their research and save costs. The result is more effective drugs getting to patients sooner.”

 

Biotech Showcase™, produced by Demy-Colton and EBD Group, is an investor and networking conference devoted to providing private and public biotechnology and life sciences companies with an opportunity to present to, and meet with, investors and pharmaceutical executives in one place during the course of one of the industry’s largest annual healthcare investor conferences, J.P. Morgan Annual Healthcare Conference.

 

Sara Demy-Colton, CEO of Demy-Colton, said: “We are delighted that Cyrus Biotechnology will be presenting at Biotech Showcase this year. Biotech Showcase is the perfect platform for life science companies to showcase their innovation and seek out their next deal. This year again we are thrilled to be hosting what we believe will be the great business development opportunity of 2018.”

 

Background

Cyrus Biotechnology

Cyrus Biotechnology, Inc. is a privately-held biotechnology software company offering protein modeling and design capabilities to the Biopharmaceutical, Chemical, Consumer Products and Synthetic Biology industries. Cyrus was founded in 2014 as a spin-out from the University of Washington, and offers Cyrus Bench®, a Software-as-a-Service (SaaS) platform for protein structure prediction, modeling, stabilization, engineering and design to accelerate discovery of Biologics and Small Molecules. Cyrus Bench is based primarily on the Rosetta software package from Prof. David Baker’s lab at the University of Washington, along with associated software. Cyrus Bench offers the world-leading protein structure prediction pipeline of Rosetta and SparksX, the top structure prediction software in the bi-annual CASP competition and the weekly CAMEO competition, as well as the only protein engineering software experimentally proven to design new proteins completely via software. Cyrus Bench is based on over 15 years of biochemistry software development and over 400 published papers demonstrating experimental efficacy in vitro and in vivo. Cyrus is funded by experienced investors in Tech and Biotech including Trinity Ventures, Orbimed Advisors, SpringRock Ventures, W Fund and others…

 

NOTICE: The information contained in this document is dated as of December 29, 2017.  Cyrus Biotechnology, Inc. (the Company) disclaims any obligation to update such information after such date.  This document contains forward–looking statements reflecting the Company’s current expectations that necessarily involve risks and uncertainties.  Actual results and the timing of events may differ materially from those contained in such forward-looking statements due to a number of factors and the Company undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

 

Cyrus Press Release 12/29/2017

 

Contact Lucas Nivon
lucas@cyrusbio.com
206-258-6561

 

Cyrus Biotechnology Appoints Dr. David A Pearlman as Senior Fellow and Director of Customer Experience

Cyrus technology can speed new drug discovery

SEATTLE, WA November 20, 2017 — Cyrus Biotechnology, a biotechnology software company offering first-in-class tools for advanced protein modeling and discovery in drug development, announced today that it has appointed David Pearlman, Ph.D. as Senior Fellow and Director of Customer Experience.  Dr. Pearlman will lead scientific customer interactions with Cyrus’s client firms in pharmaceuticals, biotechnology therapeutics, synthetic biology and consumer products, creating a unified customer experience team. Dr. Pearlman’s team will guide users towards creating enhanced value through new engineered proteins and other compounds for a wide variety of indications using Cyrus technology.  Prior to joining Cyrus, Dr. Pearlman’s industry role was Senior Scientist and Director of Biologics Software Platform at Schrödinger, LLC, a leader in chemical simulation software and services.

 

“David has a track record of scientific innovation and market-savvy product creation in molecular modeling software that is unique. We are very fortunate to add him to our leadership team at Cyrus”, said Dr. Lucas Nivon, CEO of Cyrus. “He has played a critical role in the creation and growth of a number of innovative and market-leading firms, and has the unique blend of deep scientific understanding and customer-centric product development that will be important for Cyrus as we engage with a rapidly expanding set of customers.”

 

“The ability of computational chemistry to make significant contributions to molecular discovery has grown tremendously over my career.” said Dr. Pearlman.  “We’re now at a point where understanding, methods and computational resources are having real, measurable impact on new drug discovery. I’m particularly excited to be at Cyrus, where we are commercializing the world-class Rosetta protein design tools. The Rosetta platform has been at the heart of an incredible number of defining protein design studies over the past couple of decades.” Pearlman added.

 

Dr. Pearlman is a pioneer in the field of computational chemistry. He was a founding product manager at Biosym Technologies (later BIOVIA), an early employee of Vertex Pharmaceuticals, and led development of the biologics software platform (BioLuminate) at Schrödinger, LLC. He was also, for many years, first author and a principal developer of the widely-used AMBER simulation platform. He has published a long string of seminal papers in the area of free energy perturbation, and extensively on topics such as NMR refinement and de novo ligand design and scoring.

 

Background

Cyrus Biotechnology

Cyrus Biotechnology, Inc. is a privately-held biotechnology software company offering protein modeling and design capabilities to the Biopharmaceutical, Chemical, Consumer Products and Synthetic Biology industries. Cyrus was founded in 2014 as a spin-out from the University of Washington, and offers Cyrus Bench®, a Software-as-a-Service (SaaS) platform for protein structure prediction, modeling, stabilization, engineering and design to accelerate discovery of Biologics and Small Molecules. Cyrus Bench is based primarily on the Rosetta software package from Prof. David Baker’s lab at the University of Washington, along with associated software. Cyrus Bench offers the world-leading protein structure prediction pipeline of Rosetta and SparksX, the top structure prediction software in the bi-annual CASP competition and the weekly CAMEO competition, as well as the only protein engineering software experimentally proven to design new proteins completely via software. Cyrus Bench is based on over 15 years of biochemistry software development and over 400 published papers demonstrating experimental efficacy in vitro and in vivo. Cyrus is funded by experienced investors in Tech and Biotech including Trinity Ventures, Orbimed Advisors, SpringRock Ventures, W Fund and others…

 

NOTICE: The information contained in this document is dated as of November 20, 2017.  Cyrus Biotechnology, Inc. (the Company) disclaims any obligation to update such information after such date.  This document contains forward–looking statements reflecting the Company’s current expectations that necessarily involve risks and uncertainties.  Actual results and the timing of events may differ materially from those contained in such forward-looking statements due to a number of factors and the Company undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

 

Cyrus Press Release 11/20/2017

 

Contact Lucas Nivon
lucas@cyrusbio.com
206-258-6561

 

Cyrus Bio Featured in US Pharmaceutical Industry Weekly Report

Cyrus Bio CEO, Lucas Nivon, was interviewed by MSA Partners for the October 20, 2017 issue of the US Pharmaceutical Industry Weekly Report. Please contact MSA Partners to subscribe to the newsletter.

About MSA Partners
Founded in 1983, MSA Partners’ mission is to provide Japanese organizations with means and ways to realize and grow their business potential in the US market. As the challenges faced by Japanese organizations doing business in the US have grown increasingly complex over the years, MSA’s integrated and creative approach has become ever more valuable to its clients. MSA takes a team-based approach to combine the skills and expertise of both American and Japanese professionals from MSA, supplement these with outside skills when necessary, and work closely with clients to accomplish their goals. With over 25 years of experience, MSA offers a diverse range of interrelated research, consulting, communications and positioning services, to provide in-depth, comprehensive support to clients. Recognizing that one of the keys to quickly seizing market opportunities is overcoming organizational and language barriers, MSA’s ability to seamlessly interface with our clients at both the head office and US subsidiary level facilitates shared understanding and decision-making.