Cyrus partners with certain academic labs to help optimize their proteins so that they can become therapeutic candidates. For example, Cyrus has worked with the Chamberlain and Odom labs at UW to computationally de-immunize (reduce the immunogenicity of) a gene therapy construct for Duchenne Muscular Dystrophy, in concert with experimental activity and immunogenicity work by our collaborators in those laboratories.
Cyrus is interested in finding the right scientific fit for academic projects, where our expertise can make a key difference in advancing a potential therapeutic molecule.
In certain cases Cyrus makes its software available at lower prices to academic labs who need basic protein engineering or structure prediction tools. For example, the industry-leading mutational free energy calculator tool in Cyrus Bench can be used in a genetics context to understand the potential physiological implications of hundreds or thousands of mutations in a population. Or a given lab may need to use computational methods to rapidly and efficiently stabilize an enzyme of interest for use in vivo.